|Formulation in Pharmacy Practice - eMixt|
A New Zealand standardised formulation is available Formula and Batch Sheet
This formula uses Ora-Blend/SF or Ora-Plus and Ora-Sweet/SF; 1:1, and has been approved by the Extemporaneous Compounding Pharmacists' Group.
Alternatives are given below.
Allopurinol is very slightly soluble in water and alcohol. The aqueous solubility is increased at alkaline pH but all published investigations have been performed on suspensions at acidic pH.
A 20mg per mL suspension, prepared from allopurinol tablets and a base consisting of one third methylcellulose solution 9% and two thirds of cherry flavored syrup, is reportedly chemically stable for at least 14 days at room temperature and under refrigeration.1
Allopurinol 20mg per mL prepared from tablets in a vehicle of Ora-Sweet and Ora-plus 1:1 or
If possible allopurinol suspension should be made in accordance with the directions of the published studies1,2 but if commercial suspending vehicles are not available the following is suggested based on evaluation of the literature.
in Pharmacy Practice
Page Updated August 2011