Amiloride hydrochloride occurs as the dihydrate and is slightly soluble
in water, with a solubility of 5.2mg per mL. Amiloride
is a weak base with a pKa of 8.7. Amiloride decomposition is
highly pH sensitive and decomposition increases with increasing pH in the
range 4-7.
Formula
Amiloride 1mg per mL |
|
| Amiloride
Tablets 5 mg |
10 |
|
| Glycerol |
20 |
mL |
| Parabens |
0.1 |
% |
| Water |
to 50 |
mL |
|
| Expiry/Stability: 21
days |
|
Storage: Refrigerate. Protect
from light.
Amber plastic containers used in the study. |
| |
|
|
|
NOTES
- A solution prepared
from amiloride hydrochloride powder was more stable than the liquid
prepared from tablets. It was stable for 30 days at room
temperature. This is due to lower apparent pH of the powder
formulation compared to the tablet formulation.
- Commercially manufactured
liquids are available in some countries.
REFERENCE
- Fawcett J.P., Woods D.J., Ferry D.G., Boulton D.W. Stability of amiloride oral
liquids prepared from tablets and powder. Aust J Hosp Pharm 1995; 25:19-23.
|