Formulation in Pharmacy Practice - eMixt

Amiloride
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Overview: Amiloride hydrochloride occurs as the dihydrate and is slightly soluble in water, with a solubility of 5.2mg per mL.  Amiloride is a weak base with a pKa of 8.7.  Amiloride decomposition is highly pH sensitive and decomposition increases with increasing pH in the range 4-7 (also see notes below).


Formula

Amiloride 1mg per mL
Amiloride Tablets 5 mg 10   
Glycerol 20  mL
Parabens 0.1  %
Water to   50  mL
Expiry/Stability:  21 days
Storage:  Refrigerate.  Protect from light.
Amber plastic containers used in the study.
 

 
NOTES
  1. A solution prepared from amiloride hydrochloride powder was more stable than the liquid prepared from tablets.  It was stable for 30 days at room temperature.  This is due to lower apparent pH of the powder formulation compared to the tablet formulation.
  2. Commercially manufactured liquids are available in some countries.

REFERENCE
  1. Fawcett J.P., Woods D.J., Ferry D.G., Boulton D.W.  Stability of amiloride oral liquids prepared from tablets and powder.  Aust J Hosp Pharm 1995; 25:19-23.

 
Formulation in Pharmacy Practice
 Page Updated October 2013