Formulation in Pharmacy Practice   2nd Edition
AMIODARONE
 
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Amiodarone is very slightly soluble in water and soluble in ethanol.

Formula

Amiodarone 5mg per mL Suspension
Amiodarone tablets 200 mg 5 
Methylcellulose 1% 100  mL
Syrup 100  mL
Crush tablets to a powder using a mortar and pestle and mix with the vehicle.
Expiry: 30 days at 4°C or 25°C.
Stability: 3 months under refrigeration at 4°C or 6 weeks at 25°C.
Storage: Plastic and glass prescription bottles were used in the study.
 

 
NOTE
  1. Microbial growth was not tested so a more conservative expiry date of 30 days should be used.

REFERENCE
  1. Nahata, MC.  Stability of Amiodarone in oral suspension stored under refrigeration and at room temperature.  Ann Pharmacother 1997; 31: 851-2 [PubMed]

 
Formulation in Pharmacy Practice
Page Updated August 2011