|Formulation in Pharmacy Practice - eMixt|
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| Amitriptyline hydrochloride
is freely soluble in water but has a bitter, burning taste and local anaesthetic
properties. Commercially available suspensions are usually formulated
as amitriptyline embonate which is more palatable.
An oral liquid prepared from amitriptyline hydrochloride tablets would contain a solution of the drug and a suspension of insoluble excipients. This preparation would be relatively unpalatable.
Amitriptyline hydrochloride is reported to be stable in aqueous solution for up to 8 weeks at room temperature if protected from light.1 Amitriptyline injection has pH of
An oral liquid prepared from crushed tablets of amitriptyline hyrochloride in water may be relatively stable if stored in amber plastic containers and protected from light. However, the clinical use of such a product is probably limited by its poor taste.
in Pharmacy Practice
Page Updated August 2011