The solubility of atenolol in
water is 26.7mg per mL and it is also soluble in dehydrated
alcohol. It is poorly soluble in alkaline solutions and shows
maximum stability at pH 4.1
Formula
A2
Atenolol Oral Liquid 2mg per mL |
|
| Atenolol
tablets (Tenormin®) 100mg |
5 |
|
| *Roxane®
Diluent |
to 250 |
mL |
|
Crush the atenolol tablets to a powder using a mortar
and pestle then slowly add 50mL Roxane®
Diluent and triturate to a fine paste.
Add 200mL Roxane® Diluent to
the mortar in three equal portions, thoroughly mixing
after each dilution. |
|
| Expiry: 30
days |
|
| Stability:
40 days |
|
| Storage: Stable
at 5 - 25°C. Refrigeration recommended. |
|
| *Roxane
diluent contains; ethanol 1%, saccharin 0.05%
in a cherry flavoured 33% polyethylene glycol
8000 base. |
| |
|
|
|
Formula
B3
Atenolol Oral Liquid 2mg per mL |
| |
| Atenolol
tablets 50mg |
2 |
|
| Glycerol |
2 |
mL |
| Methylcellulose
1% |
to 50 |
mL |
|
|
Crush the tablets and make a paste with the glycerol
before adding the vehicle. |
|
| Expiry/Stability: 30
days |
|
| Storage: Stable
at 25°C but refrigeration recommended to retard
microbial growth. A preservative such
as parabens could be added. |
| |
|
|
|
NOTES
- Syrup and commercially
available bases Ora Sweet, Ora Sweet SF and Ora Plus can also be used.3
- Atenolol Injection
could be administered orally if small doses are required.
- As atenolol is
soluble in water, a simple aqueous dispersion could be prepared in which
the drug is in solution and tablet excipients are in suspension. For
example Formula B could be prepared without the suspending base. Addition
of citric acid to pH 4 - 5 will increase stability but
a maximum expiry of 7 days is suggested, as this formulation has not
been formally tested.
REFERENCES
- Hatem A, Marton
S, Csoka G, Razc I. Preformulation studies of atenolol in
oral liquid dosage form I. Effect of pH and temperature. Acta
Pharmaceutica Hungarica 1996; 66: 177-80
- Garner SS, Weist
DB, Reynolds ER. Stability of atenolol in an extemporaneously
compounded oral liquid. Am J Hosp Pharm 1994; 51: 509-11
[PubMed
Link]
- Patel D, Doshi
DH, Desai A. Short-term stability of atenolol in oral liquid
formulations. Int J Pharm Comp 1997; 1 (6):
437-439,442.
|