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A New Zealand standardised formulation is available Formula and Batch Sheet
This formula uses Ora-Blend/SF or Ora-Plus and Ora-Sweet/SF; 1:1, and has been approved by the Extemporaneous Compounding Pharmacists' Group.
Alternatives are given below.
Azathioprine is a weak base with a pKa of 8.2. Azathioprine is practically insoluble in water, but dissolves in dilute solutions of alkali hydroxides. The USP injection is azathioprine sodium and has a pH of
Azathioprine is stable in acidic or neutral conditions but is hydrolysed to mercaptopurine at alkaline pH.1 Therefore it is more appropriate to make a suspension with a neutral pH than a solution at an alkaline pH.
A suspension prepared from azathioprine tablets and a base consisting of one third methylcellulose solution 9% (Cologel) and two thirds of cherry flavored syrup, is reportedly chemically stable for at least 14 days at room temperature and under refrigeration.2
Azathioprine 50mg per mL prepared from tablets in a vehicle of Ora-Sweet and Ora-plus 1:1 or
Whenever possible azathioprine suspension should be made in accordance with the directions of the published studies2,3 but if commercial suspending vehicles are not available the following is suggested based on evaluation of the literature:
in Pharmacy Practice
Page updated September 2011