Properties
Baclofen has solubilities
of 750mg per 100mL in water and 2.4mg per 100mL in ethanol.
Alternatives to compounding
Baclofen liquid (Lioresal^{®}) is available
in some countries. Tablets
or tablet fractions may disperse in water.
Compounded formulations
A New Zealand standardised formulation (10 mg/mL) is available Formula
and Batch Sheet
This formula uses OraBlend/SF or OraPlus and OraSweet/SF; 1:1 and is
similar to formula A below.
Note: the standard strength for a compounded formulation in New Zealand
is 10 mg/mL; the standard batch sheet should be used.
Formulas A and B are based on published studies. Formula C is
based on published stability information and may be used if the commercial
suspending bases are not available or if a preparation with a syrup content
lower than formula B is preferred.
Formula
A^{2}
Baclofen Suspension 10mg per mL 

Baclofen
tablets 10mg 
120 

*Vehicle 
to 120 
mL 

*
Vehicle
A 1:1 mixture of Ora Sweet and Ora Plus, or a 1:1
mixture of Ora Sweet SF and Ora
Plus, or cherry syrup (cherry syrup concentrate
diluted 1:4 with simple syrup). 

Expiry: 30
days. 

Stability:
These preparations are chemically stable
for 60 days but microbial testing and stability
under in use conditions were not evaluated. 

Storage: Refrigerate. Protect
from light. 

Shake
well before use. 

Note
 The
final pH of these formulations is 3.2  4.7.^{2}





Formula
B ^{1}
Baclofen 5mg per mL
(NB in New Zealand please use standard formulation  see
above) 

Baclofen
(Lioresal^{®})
tablets 20mg 
15 

Glycerol 
qs 

Syrup 
to 60 
mL 

Grind tablets, add sufficient glycerol to wet the
powder and form a fine paste. Gradually
add syrup to volume. 

Expiry: 30
days. 

Storage: Refrigerate. Protect
from light. 

Shake
well before use. 

Notes
 If
unpreserved syrup is used add 0.1% parabens.
 The
formula was pleasant tasting with no after taste.





Formula
C
Baclofen Liquid 

Baclofen
tablets 
qs 

Glycerol 
20 
mL 
Syrup 
10 
mL 
Methylcellulose
1% 
50 
mL 
Parabens 
0.1 
% 
*Citric
acid 
qs 

Water 
to 100 
mL 

*
If possible check the final pH. If necessary
add a small amount of citric acid (50  100mg)
to bring the final pH approximately in the range
4  5. 

Expiry: 30
days. 

Storage: Refrigerate. Protect
from light. 

Shake
well before use. 

Note
 If
the strength is less than 5  7.5mg per
mL the baclofen should be in solution
but a suspending agent is recommended as drug
may be bound to insoluble excipients. The
drug's solubility in this system has not been
evaluated.





References
 Johnson C.E., Hart
S.M. Stability of an extemporaneously compounded baclofen
oral liquid.
Am J Hosp Pharm 1993; 50: 235355.
 Allen L. V., Erickson
M. A. Stability of baclofen, captopril, diltiazem hydrochloride,
dipyridamole, and flecainide acetate in extemporaneously compounded
oral liquids. Am J HealthSyst Pharm 1996; 53 (Sep 15);
21792184.
 Stabilis database
Baclofen
Formulation
in Pharmacy Practice

Page
Updated June 2014

