Bethanechol chloride is very
soluble in water (1.17g per mL).
Bethanechol chloride injection has a pH of 5.5 - 7.5. Optimum
pH for stability is 6.5 - 7.0.
Formula
1
Bethanechol 1mg per mL |
|
| Bethanechol
choride tablets 25mg |
4 |
|
| Sterile
Water for Irrigation |
to 100 |
mL |
|
| Filter
to remove insoluble excipients (optional). |
|
| Expiry: 30
days |
|
| Stability:
30 days |
|
| Storage: Refrigerate
(4°C). Protect from light. If
available, store in amber glass bottles. |
|
| Shake
well before use |
| |
|
|
|
NOTES
- A solution prepared from
bethanechol chloride powder was more stable than that prepared from
tablets.
- The injection can be given
orally. Dilute the injection to the desired concentration
with sterile water and maintain pH between 5.5 - 7.5.
- As this preparation is unpreserved
parabens 0.1% could be added.
- The dose can be added to
flavoured cordial prior to administration.
Alternative:
Bethanechol chloride 5mg/mL can be formulated by suspending crushed tablets
in the following vehicles.2
- a 1:1 mixture of Ora Sweet
and Ora Plus
- a 1:1 mixture of Ora Sweet
SF and Ora Plus
- or a 1:4 dilution of Cherry
Syrup concentrate with simple syrup
All formulations were stored in
amber glass containers.
The stability was 60 days at both 5°C and 25°C.2
REFERENCES
- Schlatter J.L., Saulnier
J.L. Bethanechol chloride oral solution: Stability
and use in infants.
Ann Pharmacother 1997; 31 (Mar): 294-296. [PubMed]
- Allen L.V., Erickson M.A. Stability
of bethanechol chloride, pyrazinamide, quinidine sulfate, rifampin,
and tetracycline hydrochloride in extemporaneously compounded oral liquids.
Am J Health-Syst Pharm 1998; 55 (Sep 1): 1804-1809 [PubMed]
|