Busulphan is very slightly
soluble in water (about 0.1mg per mL). The stability of extemporaneously
prepared oral liquids is not known and therefore not recommended. Tablet
dispersion is suggested and most brands disperse easily.
Large doses are required for some regimens and in this case the dose, consisting
of several 2mg tablets, can be dispersed in water and then packed into a
unit dose. The dose should be administered as soon as possible
after preparation. When giving the dose rinse the container to
ensure all the drug is removed from the container.
Myleran® brand of tablets apparently produce a reasonably
palatable suspension but nasogastric administration of large doses is often
employed to avoid spitting problems.