Formulation in Pharmacy Practice - eMixt

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Busulphan is very slightly soluble in water (about 0.1mg per mL).  The stability of extemporaneously prepared oral liquids is not known and therefore not recommended.  Tablet dispersion is suggested and most brands disperse easily.

Large doses are required for some regimens and in this case the dose, consisting of several 2mg tablets, can be dispersed in water and then packed into a unit dose.  The dose should be administered as soon as possible after preparation.  When giving the dose rinse the container to ensure all the drug is removed from the container.

Myleran® brand of tablets apparently produce a reasonably palatable suspension but nasogastric administration of large doses is often employed to avoid spitting problems.

Formulation in Pharmacy Practice