|Formulation in Pharmacy Practice 2nd Edition|
Cefuroxime axetil is an ester of cefuroxime which is well absorbed orally and then hydrolysed to active cefuroxime. A suspension is commercially available in some countries. The injectable form, cefuroxime sodium, is poorly absorbed if given orally. Cefuroxime axetil has an extremely bitter and unpleasant taste which is difficult to mask. This is a particular problem in paediatric patients who cannot swallow whole tablets or when small doses are required.
Attempts can be made to mask the unpleasant taste by dispersing the tablet in fruit juice or flavoured milk. The drug is stable in apple juice for 24 hours and for at least two hours in orange juice, grape juice or chocolate milk.1 It is recommended that such dispersions are prepared immediately prior to administration.
Pramar et al2 studied the stability of cefuroxime axetil in suspensions compounded from tablets.
Suspensions of 10mg per mL were prepared in the following bases.
Formulation in Pharmacy Practice