Formulation in Pharmacy Practice   2nd Edition

CHLOROQUINE
 
 
Chloroquine sulphate is freely soluble in water and the pH of the injection is 4 - 5.5.
Chloroquine phosphate is freely soluble in water and very slightly soluble in alcohol.
The injection has a pH of 3.5 - 4.5.
Chloroquine base 150mg is equivalent to 200mg chloroquine sulphate or 250mg chloroquine phosphate.

Formula 1

Chloroquine Sulfate 20mg per mL
 
Chloroquine sulfate tablets 200mg 10   
Syrup to   100  mL
 
Expiry/Stability:  30 days
 
Storage:  Protect from light.  Refrigerate.
 
Shake Before Use
 

 
NOTE
  1. Chloroquine phosphate suspension can also be formulated using six chloroquine phosphate 250mg tablets to 100mL with a 1:1 mixture of Ora Sweet:Ora Plus.2

REFERENCES
  1. Closson R.G.  Liquid dosage form of chloroquine.  Drug Intelligence and Clinical Pharmacy 1988; 22: 347.
  2. Allen L.V., Eriksen M.A.  Stability of alprazolam, chloroquine phosphate, cisapride, enalapril maleate and hydralazine hydrochloride in extemporaneously compounded oral liquids. Am J Health-Syst Pharm 1999; 55: 1915-20. [PubMed Link]

 
Formulation in Pharmacy Practice
2nd Edition