Ciprofloxacin is practically insoluble
in water and ethanol. It has a bitter taste.
The commercially available ciprofloxacin suspension should be used whenever possible, as it is formulated to mask the bitter taste of the drug. Tablets are available in a variety of sizes and they usually disperse readily in water.
Formula 1
Ciprofloxacin Suspension 50mg per mL |
| |
| Ciprofloxacin tablets 750mg |
4 |
|
| Ora-Plus |
30 |
mL |
| Syrup |
30 |
mL |
| |
|
Premix the Ora-Plus and syrup and wet the powdered tablets with a small amount of the mixture to form
a paste. Gradually add the rest of the vehicle and make to volume. |
| |
| Expiry: 30
days |
| |
|
Stability:
Chemically stable for 56 days. |
| |
|
Storage: Refrigeration or 24 - 26°C. |
| |
|
Shake well before use |
| |
|
|
|
NOTES
- The final pH of this preparation is about 4.5.
- The suspension is bitter with a prolonged aftertaste. Palatability can be improved by
mixing with chocolate syrup just prior to giving the dose.
- The oral bioavailability of ciprofloxacin from this formulation has not been assessed.
- If Ora-Plus is not available a simple base consisting of a 1:1 mixture of methylcellulose 1%
and syrup, preserved with parabens is suggested.
- There are anecdotal reports that some extemporaneously prepared ciprofloxacin suspensions have poor
physical characteristics, e.g. flocculation and solidification. Physical characteristics
should be observed. The commercially available oral liquid or a tablet dispersion should
be used whenever possible.
REFERENCE
- Johnson CE, Wong DV, Hoppe HL, Bhatt-Mehta V. Stability of ciprofloxacin in an
extemporaneous oral liquid dosage form. Int J Pharm Comp 1998: 2 (4): 314-317.
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