Formulation in Pharmacy Practice   2nd Edition

Ciprofloxacin is practically insoluble in water and ethanol.  It has a bitter taste.
The commercially available ciprofloxacin suspension should be used whenever possible, as it is formulated to mask the bitter taste of the drug.  Tablets are available in a variety of sizes and they usually disperse readily in water.

Formula 1

Ciprofloxacin Suspension 50mg per mL
Ciprofloxacin tablets  750mg  
Ora-Plus 30  mL
Syrup 30  mL
Premix the Ora-Plus and syrup and wet the powdered tablets with a small amount of the mixture to form a paste.  Gradually add the rest of the vehicle and make to volume.
Expiry:  30 days
Stability:   Chemically stable for 56 days.
Storage:  Refrigeration or 24 - 26°C.
Shake well before use

  1. The final pH of this preparation is about 4.5.
  2. The suspension is bitter with a prolonged aftertaste.  Palatability can be improved by mixing with chocolate syrup just prior to giving the dose.
  3. The oral bioavailability of ciprofloxacin from this formulation has not been assessed.
  4. If Ora-Plus is not available a simple base consisting of a 1:1 mixture of methylcellulose 1% and syrup, preserved with parabens is suggested.
  5. There are anecdotal reports that some extemporaneously prepared ciprofloxacin suspensions have poor physical characteristics, e.g. flocculation and solidification.  Physical characteristics should be observed.  The commercially available oral liquid or a tablet dispersion should be used whenever possible.

  1. Johnson CE, Wong DV, Hoppe HL, Bhatt-Mehta V.  Stability of ciprofloxacin in an extemporaneous oral liquid dosage form.  Int J Pharm Comp 1998: 2 (4): 314-317.

Formulation in Pharmacy Practice
2nd Edition
© 2001 PharmInfoTech
ISBN 0-473-07577-6