|Formulation in Pharmacy Practice|
No published stability studies of extemporaneously prepared clobazam suspensions have been located.
Clobazam is slightly
soluble in water and at a typical concentration of 1 mg/mL most of the
drug will be in suspension. Significant degradation of clobazam in aqueous
suspension is not expected over short periods of use.
The optimum pH for stability is not known.
No formal stability
studies of clobazam suspension prepared with Ora-Blend or Ora-Plus, or
other commercial bases have been conducted.
Clobazam tablets to
give a final concentration of 1 mg per mL
Different brands of clobazam may produce suspensions with variable characteristics. A trial batch before patient use may be appropriate.
1. Jackson and Lowey,
of Extemporaneous Preparation; Pharmaceutical Press, 2010
in Pharmacy Practice
Page Updated: September 2011