Formulation in Pharmacy Practice   2nd Edition

CORTISONE ACETATE

 

Cortisone acetate is insoluble in water and slightly soluble in alcohol.  The following formulation has been suggested1 but there is no published information on the stability of extemporaneously prepared suspensions. Formula Cortisone Suspension 5mg per 5mL   Cortisone Acetate 100  mg Polysorbate 80 0.5  mL #Base to   100  mL   The polysorbate 80 is used to wet the tablets.  If not available use a small amount of ethanol.   Expiry:  The original suggestion was 1 month but 7 days may be more appropriate due to lack of stability information.   Storage:  Refrigerate.   Shake well before use     #Formula for the base Sodium carboxymethylcellulose 1  g Syrup 10  mL Methyl hydroxybenzoate 150  mg Citric acid monohydrate 600  mg Lemon spirit 0.25  mL Water to   100  mL   Dissolve the methyl hydroxybenzoate and citric acid in hot water.  Add the syrup and lemon spirit and make up to 75mL with water then add the sodium carboxymethylcellulose and mix.   Allow to hydrate for about one hour then make up to volume.     REFERENCE Anderson S.  A Formulary of Paediatric preparations.  Guild of Hospital Pharmacists (UK); 1978: 9.

 

Formulation in Pharmacy Practice 2nd Edition