Formulation in Pharmacy Practice   2nd Edition

CORTISONE ACETATE
 
 
Cortisone acetate is insoluble in water and slightly soluble in alcohol.  The following formulation has been suggested1 but there is no published information on the stability of extemporaneously prepared suspensions.

Formula

Cortisone Suspension 5mg per 5mL
 
Cortisone Acetate 100  mg
Polysorbate 80 0.5  mL
#Base to   100  mL
 
The polysorbate 80 is used to wet the tablets.  If not available use a small amount of ethanol.
 
Expiry:  The original suggestion was 1 month but 7 days may be more appropriate due to lack of stability information.
 
Storage:  Refrigerate.
 
Shake well before use
 
 
#Formula for the base
Sodium carboxymethylcellulose g
Syrup 10  mL
Methyl hydroxybenzoate 150  mg
Citric acid monohydrate 600  mg
Lemon spirit 0.25  mL
Water to   100  mL
 
Dissolve the methyl hydroxybenzoate and citric acid in hot water.  Add the syrup and lemon spirit and make up to 75mL with water then add the sodium carboxymethylcellulose and mix.   Allow to hydrate for about one hour then make up to volume.
 

 
REFERENCE
  1. Anderson S.  A Formulary of Paediatric preparations.  Guild of Hospital Pharmacists (UK); 1978: 9.
 
 
     

 
Formulation in Pharmacy Practice
2nd Edition