|Formulation in Pharmacy Practice 2nd Edition|
Dantrolene is a weak acid with a pKa of about 7.5.
Dantrolene sodium is slightly soluble in water but free dantrolene tends to precipitate out of solution especially in acidic conditions. Sodium hydroxide is included in the formulation of the injection to give a pH after reconstitution of about 9.5.
Reconstituted dantrolene sodium injection is reported to be stable for only 6 hours at
The injection would be considered too expensive to give orally.
Formulation in Pharmacy Practice