Formulation in Pharmacy Practice  - eMixt

Dexamethasone
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Properties
Dexamethasone is practically insoluble in water and sparingly soluble in alcohol. Dexamethasone sodium phosphate (injectable formulations) is soluble in water.

Compounding alternatives
Oral liquids (some containing ethanol) are commercially available in some countries.
Some tablet formulations disperse readily in water and tablets are often scored allowing administration of fractional doses.  The injection (dexamethasone sodium phosphate) is sometimes administered orally.1  

 

Compounding options
Dexamethasone sodium phosphate 1 mg/mL 2 

Dexamethasone sodium phosphate injection 4 mg/mL; 50 mL

Ora-Plus/Ora-Sweet; 50:50 mixture to 200 mL

Dexamethasone 1 mg/mL 3,4 

This formula includes ethanol and propylene gycol which may nor bwe suitable for children. Dexamethasone powder was used and stability cannot be extrapolated to formulations prepared from tablets.

References/bibliography
  1. Can kids be given injectable dexamethasone orally ? Available from: http://www.medscape.com/viewarticle/758927 (accessed June, 2014)
  2. Wen-Lin Chou et al. Can J Hosp Pharm 2001:54:96-101
  3. Accordino A., Chambers R., Thompson B.  A short-term stability study of an oral solution of dexamethasone.  Aust J Hosp Pharm 1994, 24(4); 312-316.
  4. Stabilis database (dexamethasone)
  5. Stabilis database (dexamethasone sodium phosphate)
Formulation in Pharmacy Practice eMixt
Page updated June 2014