|Formulation in Pharmacy Practice - eMixt|
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Diazoxide is practically insoluble in a water, slightly soluble in alcohol and very soluble in alkaline solutions. Diazoxide has a pKa of 8.5. The injection is a sterile solution of the drug in water for injection made with the addition of sodium hydroxide; the pH is about 11.6. Solutions and suspensions of diazoxide are light sensitive and may darken on exposure to heat and light. Darkened preparations are likely to be subpotent. Oral suspensions are available in some countries and may contain parabens and about 7% ethanol. Formal stability studies of extemporaneous preparations have not been located.
Alternatives to compounding
In New Zealand a 50mg/ml proprietary product is available as an unregistered product. Please refer to additional important information.
Important safety note: the proprietary product is a different strength to compounded formulations - extreme care is required to avoid confusion and possible overdose.
The following formula has been suggested (Jackson and Lowey, Handbook of Extemporaneous Preparation; Pharmaceutical Press, 2010)
Diazoxide 10 mg/mL Suspension
Diazoxide 50 mg tablets x 20
Ora-Plus 50 mL
Ora-Sweet or Ora-Plus SF to 100 mL.
Shelf-life, 7 days at room temperature. Shake the bottle.
An alternative formula is based on the information available, is as follows:
in Pharmacy Practice
Page Updated June 2014