Formulation in Pharmacy Practice - eMixt

Dipyridamole
 
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A New Zealand standardised formulation is available Formula and Batch Sheet
This formula uses Ora-Blend/SF or Ora-Plus and Ora-Sweet/SF; 1:1, and has been approved by the Extemporaneous Compounding Pharmacists' Group.
Alternatives are given below.


Dipyridamole is practically insoluble in water and very soluble in alcohol.  It has a bitter taste.
Formula A is preferred but Formula B is suggested if the commercial vehicle is not available.

Formula A1

Dipyridamole Suspension 10mg per mL
 
Dipyridamole tablets 50mg 24 
*Vehicle to   120  mL
*A 1:1 mixture of Ora-Sweet and Ora-Plus, or Ora-Sweet SF and Ora-Plus, or Cherry syrup.
Expiry:  30 days
Stability:   Chemicaly stable for 60 days but no microbial testing or in use evaluation performed.
Storage:  5°C or 25°C.  Protect from light.
Shake well before use
Note
  1. The pH of this formulation was in the range 3.4 - 4.3.
 

 
Formula B

Dipyridamole Suspension
Dipyridamole tablets qs 
Methylcellulose 1% 50  mL
Glycerol 20  mL
Syrup 10  mL
Parabens 0.1  %
Water to   100  mL
Expiry:  30 days
Storage:  Refrigerate.  Protect from light.
Shake well before use
 

 
REFERENCE
  1. Allen Jr LV and Erickson II MA.  Stability of baclofen, captopril, diltiazem hydrochloride, dipyridamole and flecainide acetate in extemporaneously compounded oral liquids.  Am J Health-Syst Pharm 1996; 53: 2179-84.

 
Formulation in Pharmacy Practice
Page Updated: September 2011