|Formulation in Pharmacy Practice - eMixt|
Oral liquids are available in some countries; they usually contain sorbitol, microcrystalline cellulose, sodium carboxymethylcellulose, methyl
FormulationsA New Zealand standardised formulation is available Formula and Batch Sheet
This formula uses Ora-Blend/SF or Ora-Plus and Ora-Sweet/SF; 1:1. Alternatives are given below.
Domperidone suspensions of both 1 and 10 mg/mL in a 1:1 mixture of Ora-Sweet and Ora-Plus were reported to be physically and chemically stable for a period of up to 91 days, both at room temperature and under refrigeration. The pH of the suspensions ranged from about 4.3 - 4.6 (1)
The formula suggested below is a possible alternative If the commercial base is not available. Add citric acid to ensure the pH is in the range quoted above and assign a more conservative expiration date (30 days suggested).
Ensom, Mary H.H., Decarie, Diane., Hamilton, Don P. Stability of Domperidone
in Extemporaneously Compounded Suspensions. Journal of Informed Pharmacotherapy
in Pharmacy Practice
Page updated June 2014