Formulation in Pharmacy Practice  - eMixt

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Compounding alternatives
Oral liquids are available in some countries; they usually contain sorbitol, microcrystalline cellulose, sodium carboxymethylcellulose, methyl p-hydroxybenzoate, propyl p-hydroxybenzoate, sodium saccharin, polysorbate 20 , sodium hydroxide, and purified water. Some tablet formulations disperse easily.
FormulationsA New Zealand standardised formulation is available Formula and Batch Sheet
This formula uses Ora-Blend/SF or Ora-Plus and Ora-Sweet/SF; 1:1. Alternatives are given below.

Domperidone suspensions of both 1 and 10 mg/mL in a 1:1 mixture of Ora-Sweet and Ora-Plus were reported to be physically and chemically stable for a period of up to 91 days, both at room temperature and under refrigeration. The pH of the suspensions ranged from about 4.3 - 4.6 (1)

The formula suggested below is a possible alternative If the commercial base is not available. Add citric acid to ensure the pH is in the range quoted above and assign a more conservative expiration date (30 days suggested).


Domperidone Suspension 1mg per mL
Domperidone tablets 10mg 10 
Glycerol 20  mL
Methylcellulose 1% 50  mL
Parabens 0.1  %
Water to   100  mL
Expiry:  30 days.
Storage:  Refrigerate.  Protect from light.
Shake well before use


1. Ensom, Mary H.H., Decarie, Diane., Hamilton, Don P. Stability of Domperidone in Extemporaneously Compounded Suspensions. Journal of Informed Pharmacotherapy 2002;8 (Jan-Mar)

Formulation in Pharmacy Practice
Page updated June 2014