|Formulation in Pharmacy Practice|
| An oral liquid, Motilium® Suspension,
is available in some countries. It contains sorbitol, microcrystalline
cellulose, sodium carboxymethylcellulose, methyl
Domperidone suspensions of both 1 and 10 mg/mL in a 1:1 mixture of Ora-Sweet and Ora-Plus were reported to be physically and chemically stable for a period of up to 91 days, both at room temperature and under refrigeration. An expiration date of 91 days was suggested. The pH of the suspensions ranged from about 4.3 - 4.6.
Ensom, Mary H.H., Decarie, Diane., Hamilton, Don P. Stability of Domperidone in Extemporaneously Compounded Suspensions. Journal of Informed Pharmacotherapy 2002;8 (Jan-Mar)
NB Ora-Sweet and Ora-Plus are not available in most countries outside USA and Canada. The formula suggested below is a possible alternative as the ingredients are similar to the components of Ora-Plus. Add citric acid to ensure the pH is in the range quoted above and assign a more conservative expiration date (30 days suggested).
Formulation in Pharmacy Practice