Fludrocortisone acetate is insoluble in water and sparingly soluble in alcohol.
Formal stability studies of suspensions of fludrocortisone have not been located.
This formula is based on a previous recommendation by the manufacturer of Florinef
® tablets.
Formula
Fludrocortisone Suspension |
| |
| Fludrocortisone acetate tablets |
qs |
|
| Sodium Carboxymethylcellulose |
1 |
g |
| Syrup |
10 |
mL |
| Parabens |
0.1 |
% |
| Citric acid monohydrate |
600 |
mg |
| Lemon spirit (optional) |
0.25 |
mL |
| Water |
to 100 |
mL |
| |
|
If available 0.5mL of polysorbate 80 can be used to wet the crushed tablets. Alternatively use ethanol. |
| |
|
Expiry: Two weeks |
| |
|
Stability:
The suspension is reported to be stable for 44 days in amber glass
bottles, but no details of the study are available. |
| |
|
Storage: Refrigerate |
| |
|
Shake well before use |
| |
|
|
|
NOTES
- Alternative flavouring agents (e.g. chocolate or caramel) could be tried. Mix the
flavouring agent with the dose just before administration.
- Dose uniformity is essential and it is important to evaluate and observe the physical properties of the suspension. Caregivers should be counselled on the importance of re-suspension.
- Tablets usually disperse very easily and this option should be considered if the dose is a whole
tablet or easily measured fraction.
N.B. As the drug is insoluble measurement of a dose aliquot from a tablet dispersion may
lead to erratic and innaccurate dosing.
- Some pharmacists prefer to make powders or repacked capsules.
|