Formulation in Pharmacy Practice   2nd Edition

Frusemide  (Furosemide)
 
Oral liquids are commercially available world-wide and all attempts should be made to obtain them.
This information is included for use only in emergencies when there are supply problems.

Frusemide is practically insoluble in water.  The injection (frusemide sodium) is prepared with the aid of sodium hydroxide and has a pH of 8 - 9.3.  Frusemide undergoes hydrolysis in acidic media and is most stable in alkaline solution.1,2  Tablets and solutions are light sensitive.

NOTES

Recommendations
  • If practical, disperse or crush the tablet (or the fraction which corresponds to the dose) in a small volume of liquid immediately prior to administration.
  • In theory mixtures from tablets can be prepared.  Adjustment to pH 8 - 9 with sodium hydroxide should produce a solution of frusemide sodium.
    Ethanol increases, whereas sugar solutions decrease, the stability of frusemide in aqueous systems.1  The best choice of vehicle is a mixture of sorbitol and water, preferably with 5 - 10% ethanol.  Parabens are compatible with frusemide solutions.1

REFERENCES
  1. Ghanekar A.G., Das Gupta V., Gibbs C.W.  Stability of furosemide in aqueous systems.
    J Pharm Sci 1978; 67 (6): 808-811.
  2. Addicks W.  Furosemide.  In: Connors K.A., Amidon G.L., Stella V.J.
    Chemical Stability of Pharmaceuticals.  New York: John Wiley, 1986: 474-77.
 
     

 
Formulation in Pharmacy Practice
2nd Edition
© 2001 PharmInfoTech
ISBN 0-473-07577-6