Oral liquids are commercially available world-wide and all attempts should be made to obtain them.
This information is included for use only in emergencies when there are supply problems.
Frusemide is practically insoluble in water. The injection (frusemide sodium) is prepared with the aid of sodium hydroxide and has a pH of 8 - 9.3. Frusemide undergoes hydrolysis in acidic media and is most stable in alkaline solution.1,2 Tablets and solutions are light sensitive.
- If practical, disperse or crush the tablet (or the fraction which
corresponds to the dose) in a small volume of liquid immediately prior
- In theory mixtures from tablets can be prepared. Adjustment
to pH 8 - 9 with sodium hydroxide should produce a solution
of frusemide sodium.
Ethanol increases, whereas sugar solutions decrease, the stability of
frusemide in aqueous systems.1 The
best choice of vehicle is a mixture of sorbitol and water, preferably
with 5 - 10% ethanol. Parabens are compatible
with frusemide solutions.1
- Ghanekar A.G., Das Gupta V., Gibbs C.W. Stability of furosemide in aqueous systems.
J Pharm Sci 1978; 67 (6): 808-811.
- Addicks W. Furosemide. In: Connors K.A., Amidon G.L., Stella V.J.
Chemical Stability of Pharmaceuticals. New York: John Wiley, 1986: 474-77.