Formulation in Pharmacy Practice - eMixt 

Griseofulvin
 
Properties
Griseofulvin is very slightly soluble in water and sparingly soluble in alcohol.  Oral bioavailability varies with formulation and particle size. Absorption from compounded formulations is likely to be variable and unreliable.
 Suspensions are commercially available in some countries.  Formal stability studies on suspensions prepared from tablets have not been located.

 

A suggested formulation is provided below.  Due to potential problems with poor dose consistency and variable bioavailability alternatives should be considered whenever possible.  For example it may be possible to use tablet fractions, powder papers or an alternative drug.

Formula

Griseofulvin Suspension
 
*Grisoefulvin Tablets qs 
Ethanol mL
Propylene Glycol (if available) mL
Parabens 0.1  %
Methylcellulose 1% 50  mL
Water to   100  mL
*Use ultramicrosize griseofulvin tablets if available as this form has a more consistent bioavailability.
Expiry:  15 days suggested
Storage:  Room temperature or refrigeration.  Protect from light.
Shake before Use
 

 
Formulation in Pharmacy Practice