Formulation in Pharmacy Practice  

Hyoscine butylbromide
 
 
Hyoscine butylbromide oral liquid (e.g. Buscopan) is available in some countries. Hyoscine butylbromide is freely soluble in water and the injection has a pH of about 5.5. Relevant stability studies have not been located. The injection could be given orally and if necessary diluted with Water for Injection to give an easily measurable dose volume. Alternatively an oral liquid can be prepared by adding the injection or crushed tablets to a base of 40% syrup or glycerol in water with the addition of parabens 0.1 % as an antimicrobial preservative. A conservative expiry date of 14 days is suggested due to lack of confirmed stability data. Commercially available diluents such as Ora-Plus and Roxane diluent should also be suitable

Added 4/03/11 Comments or Suggestions ?
 

 
Formulation in Pharmacy Practice