Hyoscine butylbromide oral liquid (e.g. Buscopan) is available
in some countries. Hyoscine butylbromide is freely soluble in water and
the injection has a pH of about 5.5. Relevant stability studies have not
been located. The injection could be given orally and if necessary diluted
with Water for Injection to give an easily measurable dose volume. Alternatively
an oral liquid can be prepared by adding the injection or crushed tablets
to a base of 40% syrup or glycerol in water with the addition of parabens
0.1 % as an antimicrobial preservative. A conservative expiry date of 14
days is suggested due to lack of confirmed stability data. Commercially
available diluents such as Ora-Plus and Roxane diluent should also be suitable
Added 4/03/11 Comments or Suggestions
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