|Formulation in Pharmacy Practice - eMixt|
| Overview: The solubility
of labetalol hydrochloride in water is approximately 20mg per mL. Solutions
are most stable at pH
The stability of labetalol hydrochloride in distilled water, simple syrup, apple juice, grape juice and orange juice has been reported.1 Solutions were chemically stable in amber glass and plastic containers for 4 weeks. Parabens can be added to these formulations to prevent microbial growth. The stabiity of labetalol has also been reported in Ora products (see below).
Alternatives to compounding: There are few specific indications for the use of labetalol, espcially in children; other beta-blockers may be available as licensed products or specials.The injection, 5mg per mL, could be administered orally if very small doses are required. Some tablet brands may disperse.
|Formulation in Pharmacy Practice||
Page Updated August 2011