Formulation in Pharmacy Practice   2nd Edition

Loperamide is slightly soluble in water therefore at 1mg per 5mL the drug should be in solution.
Loperamide is stated to be stable at pH 2 - 9.1  The commercially available liquid contains ethanol and parabens.  The following formula is suggested:


Loperamide 1mg per 5mL
Loperamide capsules 2mg 10   
Glycerol 40  mL
Parabens 0.1  %
Water to   100  mL
Expiry:  2 weeks (suggested).
Storage:  Refrigerate.
Shake well before use

  1. A suspending agent is not necessary but it is advisable to shake the bottle in case there is any undissolved drug.

  1. McEvoy GK, ed.  AHFS Drug Information.  Bethesda MD: American Society of Health-System Pharmacists, 2000: 2617.

Formulation in Pharmacy Practice
2nd Edition