Formulation in Pharmacy Practice   2nd Edition

LOPERAMIDE
 
 
Loperamide is slightly soluble in water therefore at 1mg per 5mL the drug should be in solution.
Loperamide is stated to be stable at pH 2 - 9.1  The commercially available liquid contains ethanol and parabens.  The following formula is suggested:

Formula

Loperamide 1mg per 5mL
 
Loperamide capsules 2mg 10   
Glycerol 40  mL
Parabens 0.1  %
Water to   100  mL
 
Expiry:  2 weeks (suggested).
 
Storage:  Refrigerate.
 
Shake well before use
 

 
NOTE
  1. A suspending agent is not necessary but it is advisable to shake the bottle in case there is any undissolved drug.

REFERENCE
  1. McEvoy GK, ed.  AHFS Drug Information.  Bethesda MD: American Society of Health-System Pharmacists, 2000: 2617.

 
Formulation in Pharmacy Practice
2nd Edition