Loperamide is slightly soluble in water
therefore at 1mg per 5mL the drug should be in solution.
Loperamide is stated to be stable at pH 2 - 9.1 The commercially available liquid contains ethanol and parabens. The following formula is suggested:
Formula
Loperamide 1mg per 5mL |
| |
| Loperamide capsules 2mg |
10 |
|
| Glycerol |
40 |
mL |
| Parabens |
0.1 |
% |
| Water |
to 100 |
mL |
| |
| Expiry: 2
weeks (suggested). |
| |
|
Storage: Refrigerate. |
| |
|
Shake well before use |
| |
|
|
|
NOTE
- A suspending agent is not necessary but it is advisable to shake the bottle in case there is any undissolved drug.
REFERENCE
- McEvoy GK, ed. AHFS Drug Information. Bethesda MD: American Society of
Health-System Pharmacists, 2000: 2617.
|