Formulation in Pharmacy Practice - eMixt

Melatonin
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Overview: Extemporaneously prepared, alcohol-free, 1-mg/mL suspensions of melatonin in a 1:1 mixture of Ora-Plus and either Ora Sweet or Ora Sweet SF were stable for at least 90 days when stored amber plastic bottles at room temperature. 3 mg tablets were used in the study; in New Zealand, Country Life brand 3 mg tablets appear to make an acceptable suspension.
Note: an in use expiry date of 30 days is recommended.

Johnson CE, Cober MP, Thome T, Rouse E. Stability of an extemporaneous alcohol-free melatonin suspension. Am J Health Syst Pharm. 2011 Mar 1;68(5):420-3. doi: 10.2146/ajhp100274 [PubMed]


 
     
Formulation in Pharmacy Practice
       Page Updated November 2013