Methylphenidate hydrochloride is freely
soluble in water.
Solutions are most stable at pH 3 - 4.1 This formula has been adapted from a manufacturer's recommendation.
Formula
Methylphenidate Oral Liquid |
| |
| Methylphenidate tablets (Ritalin®) |
qs |
|
| Citric acid monohydrate |
480 |
mg |
| *Sodium Citrate |
72 |
mg |
| Parabens |
0.1 |
% |
| Glycerol |
50 |
mL |
| Water |
to 100 |
mL |
| |
| Expiry/Stability: 15
days |
| |
|
Storage: Room temperature (25°C) |
| |
|
Shake well before use |
| |
|
* Can be omitted if not available. Addition of citric acid alone (qs to pH 3 - 4) is sufficient for short term stability. |
| |
|
|
|
REFERENCE
- Connors K.A., Amidon G.L., Stella V.J. Chemical stability of pharmaceuticals, 2nd Ed. John Wiley, New York.
|