Formulation in Pharmacy Practice   2nd Edition

Methylphenidate hydrochloride is freely soluble in water.

Solutions are most stable at pH 3 - 4.1  This formula has been adapted from a manufacturer's recommendation.


Methylphenidate Oral Liquid
Methylphenidate tablets (Ritalin®) qs   
Citric acid monohydrate 480  mg
*Sodium Citrate 72  mg
Parabens 0.1  %
Glycerol 50  mL
Water to   100  mL
Expiry/Stability:  15 days
Storage:  Room temperature (25°C)
Shake well before use
*  Can be omitted if not available.  Addition of citric acid alone (qs to pH 3 - 4) is sufficient for short term stability.

  1. Connors K.A., Amidon G.L., Stella V.J.  Chemical stability of pharmaceuticals, 2nd Ed. John Wiley, New York.

Formulation in Pharmacy Practice
2nd Edition