Formulation in Pharmacy Practice - eMixt

Metoprolol tartrate


Metoprolol tartrate is very soluble in water and appears to be stable in aqueous solution.1,2


Compounding alternatives
Some tablet formulations of metoprolol tartrate may disperse in water    


A New Zealand standardised formulation is available Formula and Batch Sheet
This formula uses Ora-Blend/SF or Ora-Plus and Ora-Sweet/SF; 1:1


Peterson et al1 investigated the stability of metoprolol oral liquid but this was formulated with tragacanth and chloroform water.  Metoprolol 10mg per mL prepared from tablets in a 1:1 mixture of Ora-Sweet and Ora-Plus, or a 1:1 mixture of Ora-Sweet SF and Ora-Plus, or Cherry Syrup was stable for up to 60 days at 5°C or 25°C, protected from light.2   The final pH of these formulations ranged from 3.4 - 5.4.1,2 


  1. Peterson G.M., Meaney M.F., Reid C.A., Taylor G.R.   Stability of extemporaneously prepared mixtures of metoprolol and spironolactone.  Aust J Hosp Pharm 1989; 19 (6): 344-46.
  2. Allen L.V., Erickson M.A.  Stability of labetalol hydrochloride, metoprolol tartrate, verapamil hydrochloride and spironolactone with hydrochlorothiazide in extemporaneously compounded oral liquids. Am J Health-Syst Pharm 1996; 53: 2304-9
  3. Secundem Artem Volume 6 no.1.
  4. Metoprolol tartrate Stabilis database




Formulation in Pharmacy Practice
   Page updated June 2014