Formulation in Pharmacy Practice - eMixt

Metoprolol tartrate
 

Properties

Metoprolol tartrate is very soluble in water and appears to be stable in aqueous solution.1,2

 

Compounding alternatives
Some tablet formulations of metoprolol tartrate may disperse in water    

Formulations

A New Zealand standardised formulation is available Formula and Batch Sheet
This formula uses Ora-Blend/SF or Ora-Plus and Ora-Sweet/SF; 1:1


Alternatives

Peterson et al1 investigated the stability of metoprolol oral liquid but this was formulated with tragacanth and chloroform water.  Metoprolol 10mg per mL prepared from tablets in a 1:1 mixture of Ora-Sweet and Ora-Plus, or a 1:1 mixture of Ora-Sweet SF and Ora-Plus, or Cherry Syrup was stable for up to 60 days at 5°C or 25°C, protected from light.2   The final pH of these formulations ranged from 3.4 - 5.4.1,2 

References/bibliography

  1. Peterson G.M., Meaney M.F., Reid C.A., Taylor G.R.   Stability of extemporaneously prepared mixtures of metoprolol and spironolactone.  Aust J Hosp Pharm 1989; 19 (6): 344-46.
  2. Allen L.V., Erickson M.A.  Stability of labetalol hydrochloride, metoprolol tartrate, verapamil hydrochloride and spironolactone with hydrochlorothiazide in extemporaneously compounded oral liquids. Am J Health-Syst Pharm 1996; 53: 2304-9
  3. Secundem Artem Volume 6 no.1.
  4. Metoprolol tartrate Stabilis database

 

 

 


Formulation in Pharmacy Practice
   Page updated June 2014