Formula
Naltrexone Liquid 1mg per mL |
| |
| Naltrexone Tablets 50mg |
2 |
|
| *Ascorbic acid |
0.5 |
g |
| #Sodium Benzoate |
0.1 |
g |
| Glycerol |
20 |
mL |
| Water |
to 100 |
mL |
| |
| #Alternatively, use parabens 0.1%. |
| |
| Expiry: 30
days. |
| |
|
Stability: 30 days at 25°C; 60 days at 4°C.1 |
| |
|
Storage: Amber, plastic bottles. |
| |
|
|
|
NOTES
- *If ascorbic acid powder is not available use a plain ascorbic acid tablet NOT effervescent as
excipients may compromise stability.
- The solution has a very bitter taste. Try mixing with fruit juice just prior to
administration.
- The above formula is based on one used by the National Institute for Drug Abuse (USA, 1976).
REFERENCE
- Fawcett J.P., Morgan N.C., Woods D.J. Formulation and stability
of naltrexone oral liquid liquid for rapid withdrawal from methadone.
Ann Pharmacother 1997; 31: 1291-4 .[PubMed
Link]
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