Formulation in Pharmacy Practice   2nd Edition

OLANZAPINE
 
 
Olanzapine is practically insoluble in water.

Formula

Olanzapine Suspension 1mg per mL
(based on reference 1) 
 
Olanzapine tablets  10mg 10   
Carboxymethylcellulose g
Parabens 0.1  %
Syrup 20  mL
Water to   100  mL
 
Expiry:  14 days.
 
Storage:  Refrigerate.  Protect from light.
 
Shake well before use
 

 
NOTES
  1. Exact details of the base were not provided.  It was described as a paediatric mixture base containing syrup, carboxymethylcellulose and parabens.
  2. Methylcellulose 1% could be used as an alternative suspending base.
  3. Olanzapine (as crushed Zyprexa® tablets) is stable for up to 6 hours at room temperature
    and up to 48 hours refrigerated in water and the following beverages; orange juice, apple juice, cola and milk.2
  4. Dispersing the tablet prior to giving the dose could be considered.
  5. As olanzapine may be irritant to the eye and can cause contact dermatitis, care in preparation and administration is advised.  When breaking or crushing olanzapine tablets it is recommended to wear gloves and wash hands before and after exposure.

REFERENCES
  1. Harvey EJ, Flanagan RJ, Taylor DM.  The preparation and stability of a liquid olanzapine preparation for oral administration in hospitals.  Pharm J 2000; 265: 275-76. [Full Text]
  2. Data on file, Lilly Reasearch Laboratories [Personal Communication, Eli Lilly and Company(NZ) Ltd. Jan 2001]

 
Formulation in Pharmacy Practice
2nd Edition