Formulation in Pharmacy Practice   2nd Edition

PROCARBAZINE
 
 
Procarbazine hydrochloride is freely soluble in water but aqueous solutions are unstable.  The drug has a bitter taste.
The preparation of powders in which the contents of the capsule are diluted with lactose has been suggested1 but there is no supporting stability information and this procedure may be hazardous.

When small oral doses are required the following procedure has been suggested.2
NB  This is a guideline only - there are no data on stability, safety or efficacy.

Taking the usual precautions for the handling of cytotoxic drugs, empty the capsule contents into a known volume of sterile water for injection.  Carefully dissolve the drug (some excipients are insoluble) and pack the required dose into an oral syringe.  Solutions must be prepared immediately prior to administration and protected from light.

REFERENCES
  1. Nahata MC, Hipple TF.  Pediatric Drug Formulations.  Cincinnati; Harvey Whitney: 1990.
  2. Woods D, Hayes P, Martin T.  Practical formulation and extemporaneous products.
    New Zealand Pharmacy 1991; 11 (Dec); 16-17.
 
 
     

Formulation in Pharmacy Practice
2nd Edition