Formulation in Pharmacy Practice   2nd Edition

The solubility of ranitidine hydrochloride in water is about 660mg per mL.  An oral solution of ranitidine hydrochloride is available in most countries, it contains ethanol 7.5% and parabens.  The injection has a pH of 6.7 - 7.3 and most formulations contain 0.5% phenol.
Commercially manufactured preparations are available in most countries and should be used if possible.

Formula 1

Ranitidine 15mg per mL
Ranitidine tablets 150mg 10   
Water 50  mL
Syrup to   100  mL
Expiry:  7 days
Storage:  Refrigerate.  Protect from light.
(The storage conditions were not mentioned in the study.)
Shake well before use

  1. Karnes T.H., Harris S.R., Garnett W.R., March C.  Concentration uniformity of extemporaneously prepared ranitidine suspension.  Am J Hosp Pharm 1989; 304-7.

Formulation in Pharmacy Practice
2nd Edition