|Formulation in Pharmacy Practice|
| Sotalol hydrochloride is freely soluble in water and aqueous solutions
are stable for at least 60 days when the pH is adjusted to
The injection can be given orally and most tablet formulations disperse easily. The stability of a sotalol hydrochloride oral liquid prepared from tablets has been investigated.1
A 5mg per mL mixture was prepared by levigating Sotacor® tablets with a suspending vehicle base. The base consisted of simple syrup 30% and methylcellulose 1% gel 70%. The gel was preserved with 0.2% sodium benzoate. An expiry date of 8 weeks was recommended under refrigeration.
The following formula has been adapted from a published study.1
Sotalol has also been shown to be stable in Ora-Plus. 2 [Ref]
Formulation in Pharmacy Practice