|Formulation in Pharmacy Practice 2nd Edition|
Sucralfate is practically insoluble in water and ethanol, but 1g sucralfate tablets can be rapidly dispersed in about 10ml of water.
There are a number of reports that describe the preparation of sucralfate supensions in a base of glycerol or sorbitol and water.1,2,3 In general, these suspensions are not necessary as a slurry of sucralfate dispersed in water can be given to patients who are unable to swallow tablets. If necessary, a suitable flavouring agent or sweetener (eg syrup or glycerol) can be added after the tablet has dispersed.
A method has been suggested for nasogastric administration.1
Formulation in Pharmacy Practice