Formulation in Pharmacy Practice   2nd Edition

SUCRALFATE
 
 
Sucralfate is practically insoluble in water and ethanol, but 1g sucralfate tablets can be rapidly dispersed in about 10ml of water.
There are a number of reports that describe the preparation of sucralfate supensions in a base of glycerol or sorbitol and water.1,2,3  In general, these suspensions are not necessary as a slurry of sucralfate dispersed in water can be given to patients who are unable to swallow tablets.   If necessary, a suitable flavouring agent or sweetener (eg syrup or glycerol) can be added after the tablet has dispersed.

A method has been suggested for nasogastric administration.1

  1. Remove the cap and plunger from a 60mL syringe and place the sucralfate tablet inside.
  2. Replace the plunger so that minimal airspace exists around the tablet and draw up about 20mL of water into the syringe.
  3. Replace cap and allow the syringe to stand for about for 5 minutes, shaking occasionally.
  4. Shake the suspension and administer directly from the syringe into the tube.

NOTE
  1. It is important to flush the tubing before and after nasogastric administration of sucralfate to avoid any binding interactions with other drugs or feeds.

REFERENCES
  1. Schneider JS, Ouellette SM.  Sucralfate administration via nasogastric tube.  N Engl J Med 1984; 310 (15): 990.
  2. Kostka MD, Frisolone J, Rudnick E.  Making decisons about drug repackaging.  Am J Health Syst Pharm 1996; 53: 564-65.
  3. Ferraro JM.  Sucralfate suspension for mouth ulcers.  Drug Intell Clin Pharm 1985; 19: 480.

 
Formulation in Pharmacy Practice
2nd Edition