Formulation in Pharmacy Practice  - eMixt

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Terbinafine hydrochloride is soluble in ethanol and slightly soluble in water.


A New Zealand standardised formula is available Formula and Batch Sheet
This formula uses Ora-Blend or Ora-Plus and Ora-Sweet in equal parts; final pH about 5.5.

If these commercial bases are unavailable the following formula is suggested.

Terbinafine Suspension
Terbinafine Tablets qs 
Glycerol 20  mL
Methylcellulose 1% 50  mL
Parabens 0.1  %
Citric acid 50  mg
Water to   100  mL
The final pH should be 5.5 or lower.
Expiry:  30 days (suggested)
Storage:  Refrigeration or room temperature
Shake well before use

  1. Abdel-Rahman S.M., Nahata M.C.  Stability of terbinafine hydrochloride in an extemporaneously prepared oral suspension at 25 and 4°C.  
    Am J Health-Syst Pharm 1999; 56: 243-5.[PubMed Link]
Formulation in Pharmacy Practice
Page Updated  March 2014