Terbinafine hydrochloride is soluble in ethanol and slightly soluble in water.
Formula A uses a commercially available vehicle. Formula B is a suggested alternative if the vehicle is not available.
Formula A1
Terbinafine Suspension 25mg per mL |
| |
| Terbinafine Tablets 250mg |
10 |
|
| Ora-Sweet, Ora-Plus; 1:1 mixture |
to 100 |
mL |
| |
| The final pH of this preparation is about 5.5 |
| |
| Expiry: 30
days |
| |
|
Stability:
42 days |
| |
|
Storage: 4 - 25°C |
| |
|
Shake well before use |
| |
|
|
|
Formula B
Terbinafine Suspension |
| |
| Terbinafine Tablets |
qs |
|
| Glycerol |
20 |
mL |
| Methylcellulose 1% |
50 |
mL |
| Parabens |
0.1 |
% |
| Citric acid |
50 |
mg |
| Water |
to 100 |
mL |
| |
| The final pH should be 5.5 or lower. |
| |
| Expiry: 30
days (suggested) |
| |
|
Storage: Refrigeration or room temperature |
| |
|
Shake well before use |
| |
|
|
|
REFERENCE
- Abdel-Rahman S.M., Nahata M.C. Stability of terbinafine
hydrochloride in an extemporaneously prepared oral suspension at 25
and 4°C.
Am J Health-Syst Pharm 1999; 56: 243-5.[PubMed
Link]
|