Levothyroxine sodium has an aqueous solubility of 150 micrograms per
mL at 25°C.
The compound is also sensitive to light and pH.1
Formula
A1
Thyroxine 25 micrograms per mL |
| |
| Levothyroxine sodium tablets 100
micrograms |
25 |
|
| Glycerol |
40 |
mL |
| Water |
to 100 |
mL |
| |
Method:
- Grind up tablets.
- Mix up with 10mL aliquots of glycerol until
all
the glycerol is used up.
- Bring up to volume (100mL) with water.
|
| |
| Stability: 8
days. |
| |
Storage: Stable under
refrigeration and at room temperatures
(temperatures above 27°C should be
avoided).
Store in amber
bottles. Preservative not necessary
with such a short expiry date, especially if
refrigerated. |
| | | | |
REFERENCE
- Boulton D.J., Fawcett J.P., Woods D.J. Stability of an
extemporaneously compounded levothyroxine sodium oral
liquid. Am J Health Syst Pharm 1996; 53:
1157-61.
|