|Formulation in Pharmacy Practice - eMixt|
Trimethoprim is practically insoluble in water (0.004mg per mL, at room temperature).
Tablets or tablet fractions may disperse in water. Manufactured products such as "specials" are also available.
The current recommendation using a base of methylcellulose and syrup is based on the only published stability study.1
At present there are no data to support the use of Ora-Blend or Ora-Plus/Ora-Sweet to prepare trimethoprim suspension. However, available data suggest that trimethorom should be stable for at least 30 days in these bases.
2.Stabilis database Trimethoprim