|Formulation in Pharmacy Practice - eMixt|
| Verapamil hydrochloride is
soluble in water, 1 in 20, with a bitter taste.
Aqueous solutions of 0.5mg per mL are reported to be very stable and the optimum pH range for stability is
The injection, 2.5mg per mL, has a pH of 4.1 - 6. Precipitation may occur in solutions having a pH of greater
A New Zealand standardised formula is available Formula and Batch Sheet
This formula uses Ora-Blend/SF or Ora-Plus and Ora-Sweet/SF in equal parts, and has been approved by the Extemporaneous Compounding Pharmacists' Group.
Verapamil hydrochloride 50mg per mL, prepared from tablets in a 1:1 mixture of Ora-Sweet and Ora-Plus, or a 1:1 mixture of Ora-Sweet SF and Ora-Plus or Cherry Syrup was stable for up to 60 days at 5°C or 25°C, protected from light.2 The final pH of these preparations was in the range
If these commercial bases are unavailable the following formula is suggested based on a review of the literature.
in Pharmacy Practice
Page Updated March 2014